Basic medical microbiology

Authors : Murray, Patrick R.
Edition :
Year : 2018
Description :

Authored by the lead author of the bestselling 'Medical Microbiology' and written in the same tradition, 'Basic Medical Microbiology' was designed as a straight-forward, practical introduction to this difficult topic. It provides students with a firm foundation in the principles and applications of microbiology, serving as an effective prep tool for examinations and the transition into clinical application. Carefully curated contents focus on the most commonly observed and tested organisms and diseases.

• Aerobic gram-positive cocci --
• Aerobic gram-positive rods --
• Acid-fast bacteria --
• Aerobic gram-negative cocci and coccobacilli --
• Aerobic fermentative gram-negative rods --
• Aerobic non-fermentative gram-negative rods --
• Anaerobic bacteria --
• Spiral shaped bacteria --
• Intracellular bacteria --
• Introduction to viruses --
• Human immunodeficiency viruses --
• Human herpes viruses --
• Respiratory viruses --
• Hepatitis viruses --
• Gastrointestinal viruses --
• Introduction to fungi --
• Cutaneous and subcutaneous fungi --
• Systemic dimorphic fungi --
• Opportunistic fungi --
• Introduction to parasites --
• Protozoa --
• Nematodes --
• Trematodes --
• Cestodes --
• Arthropods.

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Vaccine Development and Manufacturing

Authors : Emily P. Wen, Ronald Ellis, Narahari S. Pujar
Edition : 1
Year : 2014
Description :

Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up.

Highlights include:

Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agenciesAuthors from different major pharmaceutical and biotechnology companiesDescribes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market


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Virus-like Particles in Vaccine Development

Authors : Buonaguro, F.M.; Buonaguro, L.
Edition : 1
Year : 2014
Description :

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Vaccine Nation: America's Changing Relationship with Immunization

Authors : Elena Conis
Edition : 1
Year : 2014
Description :

With employers offering free flu shots and pharmacies expanding into one-stop shops to prevent everything from shingles to tetanus, vaccines are ubiquitous in contemporary life. The past fifty years have witnessed an enormous upsurge in vaccines and immunization in the United States: American children now receive more vaccines than any previous generation, and laws requiring their immunization against a litany of diseases are standard. Yet, while vaccination rates have soared and cases of preventable infections have plummeted, an increasingly vocal cross section of Americans have questioned the safety and necessity of vaccines. In Vaccine Nation, Elena Conis explores this complicated history and its consequences for personal and public health.

Vaccine Nation opens in the 1960s, when government scientists—triumphant following successes combating polio and smallpox—considered how the country might deploy new vaccines against what they called the “milder” diseases, including measles, mumps, and rubella. In the years that followed, Conis reveals, vaccines fundamentally changed how medical professionals, policy administrators, and ordinary Americans came to perceive the diseases they were designed to prevent. She brings this history up to the present with an insightful look at the past decade’s controversy over the implementation of the Gardasil vaccine for HPV, which sparked extensive debate because of its focus on adolescent girls and young women. Through this and other examples, Conis demonstrates how the acceptance of vaccines and vaccination policies has been as contingent on political and social concerns as on scientific findings.

By setting the complex story of American vaccination within the country’s broader history, Vaccine Nation goes beyond the simple story of the triumph of science over disease and provides a new and perceptive account of the role of politics and social forces in medicine.


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The Vaccine Court: The Dark Truth of America's Vaccine Injury Compensation Program

Authors : Wayne Rohde
Edition :
Year : 2014
Description :

A hard look at the National Vaccine Injury Compensation Program and the families desperately trying to navigate their way through it.

The Vaccine Court looks at the mysterious and often unknown world of the National Vaccine Injury Compensation Program (NVICP), the only recourse for seeking compensation for those who have been injured by a vaccine. The NVICP, better known as the ”Vaccine Court,” however, is not without controversy.

Established by Congress as a direct result of the passage of the National Childhood Vaccine Injury Act of 1986, the NVICP was supposed to offer a no-fault alternative to the traditional injury claims filed in state or federal courts and was to provide quick, efficient, and fair compensation for those who have been injured by vaccines. The reality, however, is that many cases take several years or longer to complete and require tremendous commitment from families already pushed to the brink of bankruptcy caring for the vaccine-injured family member, only to discover that the end result is manipulated by the government in defense of the US vaccine policy.

Mr. Rohde looks into the inner workings of the US Federal Claims Court and the NVICP. He interviews families who have filed petitions and won compensation, families who have been denied compensation, and families still waiting for a decision. By highlighting the journeys of these families—their efforts to find attorneys willing to represent them, the filing of their petitions, and the subsequent mountain of paperwork, medical records, and other documents that span years—Mr. Rohde exposes the bitter truth behind the NVICP. Through his thoughtful interviews and fact-finding research, The Vaccine Court sheds light on how the NVICP has evolved into something far more treacherous than what Congress envisioned with the National Childhood Vaccine Injury Act in 1986.


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Vaccine Injuries: Documented Adverse Reactions to Vaccines

Authors : Lou Conte, Tony Lyons
Edition : 1
Year : 2014
Description :

Reveals the truth behind the controversial issue of vaccine-related injuries.

Proponents declare that vaccines have saved millions of lives. Critics claim that the success is overstated and that vaccines may even be dangerous. Many consider mandatory vaccinations a violation of individual rights or religious principles. Many in public health argue that vaccine mandates are critical and justified and that antivaccination sentiment has resulted in outbreaks of preventable childhood illnesses. Vaccine critics point to mainstream medicine’s denial of and underreporting of vaccine injury.

Vaccine injuries have happened in the past and continue to happen today, and neither the mainstream medical establishment nor the government has ever fully and transparently addressed the issue of vaccine injury. In the 1980s, the United States addressed individual cases of vaccine injury by establishing the NVICP—the National Vaccine Injury Compensation Program—a controversial Department of Health and Human Services program. The NVICP was intended to be “non-adversarial, compassionate, and generous” to vaccine-injury victims. However, many vaccine-injury victims and safety advocates believe that the program is not functioning as intended. There are also concerns that the program is keeping the reality of vaccine injury from public inspection.

Vaccine Injuries, a groundbreaking book in the field, reveals cases of vaccine injury from the NVICP—something that has never been offered to the public—and lets readers asses vaccine injuries for themselves.


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The Vaccine Book

Authors : Barry R. Bloom, Paul-Henri Lambert
Edition : 2
Year : 2016
Description :

The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. 

Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment.

This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child’s risk.
Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccinesGives new ideas about future vaccines and conceptsIntroduces new vaccines and conceptsGives ideas about challenges facing public and private industrial investors in the vaccine areaDiscusses the problem of declining immunization rates and vaccine hesitancy


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Micro and Nanotechnology in Vaccine Development

Authors : Mariusz Skwarczynski, Istvan Toth
Edition : 1
Year : 2017
Description :

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress.

MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles.
Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine developmentAllows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their developmentIncludes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines


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Vaccination in America

Authors : Richard J. Altenbaugh
Edition : 1
Year : 2018
Description :

The success of the polio vaccine was a remarkable breakthrough for medical science, effectively eradicating a dreaded childhood disease. It was also the largest medical experiment to use American schoolchildren. Richard J. Altenbaugh examines an uneasy conundrum in the history of vaccination: even as vaccines greatly mitigate the harm that infectious disease causes children, the process of developing these vaccines put children at great risk as research subjects. In the first half of the twentieth century, in the face of widespread resistance to vaccines, public health officials gradually medicalized American culture through mass media, public health campaigns, and the public education system. Schools supplied tens of thousands of young human subjects to researchers, school buildings became the main dispensaries of the polio antigen, and the mass immunization campaign that followed changed American public health policy in profound ways. Tapping links between bioethics, education, public health, and medical research, this book raises fundamental questions about child welfare and the tension between private and public responsibility that still fuel anxieties around vaccination today. 


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Clinical Infectious Disease

Authors : David Schlossberg
Edition : 2
Year : 2015
Description :

A fully updated version of this popular, clinically oriented, user-friendly text on infectious disease, with even more helpful graphics, tables, algorithms and images. It is packed full of information on diagnosis, differential diagnosis and therapy. In addition to the traditional organization of organ-system and pathogen-related information, this text also includes clinically helpful sections on the susceptible host (with individual chapters, for example, on the diabetic, the elderly, the injection drug user and the neonate), infections related to travel, infections related to surgery and trauma, nosocomial infection and bioterrorism. Positioned between the available encyclopedic tomes and the smaller pocket guides, this is a convenient, comprehensive and highly practical reference for all those practising in infectious diseases as well as internal or general medicine.


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Cases in Clinical Infectious Disease Practice

Authors : Okechukwu Ekenna
Edition : 1
Year : 2016
Description :

In the era of cost cutting and lack of adequate health insurance for many patients, clinical skills and time spent with patients are not adequately compensated. Yet, these dwindling and underpaid skills – good history taking, observation of and listening to patients, and physical examination of patients – remain very essential to making and reaching a complete and accurate diagnosis. Expensive laboratory and imaging diagnostics while very relevant, should not replace these age-old skills that have served to enhance and maintain the doctor-patient relationship and human connection, a connection that is often necessary for healing.

Cases in Clinical Infectious Disease Practice uses case studies to illustrate how the infectious disease clinician processes and integrates data to arrive at a diagnosis. This type of hands-on approach, invaluable in training programs, is utilized to take the reader through initial patient encounter, through the history and physical examination, to simple laboratory findings and stains, to a final diagnosis, in a way that is easily accessible to clinicians, students, and laboratory personnel working with clinical specimens.

Appeals to practitioners of all levels, with focus on patients with common problems or complications of common infections without heavy technical language Emphasizes basic clinical skills including history taking, observation, epidemiology, and physical exam, as well as simple laboratory tests, explaining how they lead to a reasonable diagnosis Presents cases seen first-hand within the community setting, reflective of cases or situations a resident or student is likely to encounter in the real world after training 
Cases in Clinical Infectious Disease Practice is an essential resource for clinicians, graduate and medical school students, and others conducting medical and clinical microbiology or infectious disease research on real patients.


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Advances in Malaria Research

Authors : Deepak Gaur, Chetan E. Chitnis, Virander S. Chauhan
Edition : 1
Year : 2017
Description :

• Thoroughly reviews our current understanding of malarial biology
• Explores the subject with insights from post-genomic technologies
• Looks broadly at the disease, vectors of infection, and treatment and prevention strategies
• A timely publication with chapters written by global researchers leaders

• 1 Introduction: An overview of malaria and Plasmodium 1
• 2 Exoerythrocytic development of Plasmodium parasites 9
• 3 Molecular basis of erythrocyte invasion by Plasmodium merozoites 33
• 4 The biology of malaria transmission 87
• 5 Comparative and functional genomics of malaria parasites 125
• 6 Gene regulation: New insights and possible intervention strategies 149
• 7 Molecular genetic approaches to malaria research 179
• 8 Transcriptomics and proteomics 197
• 9 The biochemistry of Plasmodium falciparum: An updated overview 219
• 10 Signaling in malaria parasites 291
• 11 Membrane transport proteins as therapeutic targets in malaria 307
• 12 The proteolytic repertoire of malaria parasites 325
• 13 Development of medicines for the control and elimination of malaria 353
• 14 Antimalarial drug resistance 383
• 15 Epidemiology of Plasmodium falciparum malaria 409
• 16 Malaria pathogenesis 427
• 17 Host genetics 465
• 18 The immune response in mild and severe malaria: Two sides of the same coin 495
• 19 Progress in development of malaria vaccines 521
• 20 Plasmodium vivax: Insights on burden and pathobiology 547

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Malaria: Immune Response to Infection and Vaccination

Authors : Maria M. Mota, Ana Rodriguez (eds.)
Edition : 1
Year : 2017
Description :

Currently, malaria kills more than 300,000 people per year, making it a top priority of world leaders and international organizations, who are working towards implementing and coordinating efforts to eradicate this disease. An effective malaria vaccine is recognized as the key element that will decide between success and failure in this fight. At present, despite intensive research efforts, such a vaccine is not yet available for use. However, there are a number of advanced candidate vaccines with high chances of success in the short term. 

Malaria: Immune Response to Infection and Vaccination provides a comprehensive view on the immune response to malaria and to the different vaccines under development. The book offers the following:

- Contributions by top research leaders in the field,

- Comparisons of the immune responses to both malaria infection and malaria vaccines, which are traditionally treated separately, 
- Coverage of the immune responses to the different stages of malaria, which are frequently treated as separate fields of research. 


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Complement Activation in Malaria Immunity and Pathogenesis

Authors : José A. Stoute
Edition : 1
Year : 2018
Description :

Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite. 


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Nester’s Microbiology: A Human Perspective

Authors : Denise Anderson, Sarah Salm, Deborah Allen
Edition :  8
Year :2015
Description :

Perfect for the non-major/allied health student (and also appropriate for mixed majors courses), this text provides a rock solid foundation in microbiology. By carefully and clearly explaining the fundamental concepts and offering vivid and appealing instructional art, Microbiology: A Human Perspective draws students back to their book again and again!
The text has a concise and readable style, covers the most current concepts, and gives students the knowledge and mastery necessary to understand advances of the future. A body systems approach is used in the coverage of diseases.


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Schistosoma: biology, pathology, and control

Authors : Jamieson, Barrie Gillean Molyneux
Edition : 1
Year : 2017
Description :

Features

• Explores the biology, pathology, and control of arguably the world's worst parasite
• Reviews medication and treatment for Schistosoma
• Discusses prevention and diagnosis of Schistosoma
• Relates how trapped eggs can cause human morbidity

Summary

Apart from malaria, schistosomiasis is the most prevalent parasitic infection in the world. It affects more than 200 million people in 76 tropical and subtropical countries, causing great suffering and resulting in thousands of deaths. Written by world authorities, this book examines many aspects of the biology, pathology, and control of the schistosoma parasite. Ranging in topic from infection in Pharaonic Egypt, through DNA relationships and biological systems, to advances in development of vaccines against the parasite, this book is a comprehensive text written for researchers and medical professionals alike.

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Microbiology PreTest Self-Assessment and Review

Authors : Matthew Grisham
Edition : 13
Year : 2013
Description :

PreTest is the closest you can get to seeing the test before you take it 
Great for course review and the USMLE Step 1! Microbiology: PreTest asks the right questions so you’ll know the right answers. Open it and start learning what's on the test.
500 USMLE-style questions and answers What you really need to know for exam success Detailed explanations for right and wrong answers Tested and reviewed by students who recently passed their exams

student tested and reviewed 
"I found the questions included in this book extremely well written. They covered the high-yield material of each subject and will help students better prepare for the Step 1 exam." -- Jodie Bachman, Third-Year Medical Student, University of Medicine & Dentistry of New Jersey School of Osteopathic Medicine 
"I liked this book. I feel that I would have benefited from using it during my own Step 1 study time." -- Russel Kahmke, Third-Year Medical Student, SUNY Upstate Medical University


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Candida albicans: Cellular and Molecular Biology

Authors : Rajendra Prasad (eds.)
Edition : 2
Year : 2017
Description :

This book on Candida albicans and similar pathogens provides a timely overview of the groundbreaking discoveries made in the areas of drug resistance, host–pathogen interactions, virulence, host immune system modulation, etc., in the last two decades.

This comprehensive 2nd Edition includes chapters on fungal infections, hyphal morphogenesis, molecular mechanisms of antifungal resistance, antifungal agents, multidrug transporters, virulence mechanisms in Candida albicans, host–pathogen interactions, the cell wall, fungal biofilms, lipids and antifungal resistance, signaling mechanisms and last but not the least host-immune responses. As such, it offers an ideal reference guide for mycologists, researchers, pharmacists, clinicians, and undergraduate students engaged or interested in fungal research. It will also benefit clinicians, who are required to keep abreast of the current state of research on antifungal drug resistance and antifungal development.


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The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology

Authors : Luigi Nibali, Brian Henderson (eds.)
Edition : 1
Year : 2016
Description :

Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease.

The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states.

Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section.  


The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position.
Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease 
Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.


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10% Human: How Your Body’s Microbes Hold the Key to Health and Happiness

Authors : Alanna Collen
Edition : 1
Year : 2016
Description :

You are just 10% human. For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony.

Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them. 

In this riveting, shocking, and beautifully written book, biologist Alanna Collen draws on the latest scientific research to show how our personal colony of microbes influences our weight, our immune system, our mental health, and even our choice of partner. She argues that so many of our modern diseases—obesity, autism, mental illness, digestive disorders, allergies, autoimmunity afflictions, and even cancer—have their root in our failure to cherish our most fundamental and enduring relationship: that with our personal colony of microbes. 

Many of the questions about modern diseases left unanswered by the Human Genome Project are illuminated by this new science. And the good news is that unlike our human cells, we can change our microbes for the better. Collen’s book is a revelatory and indispensable guide. It is science writing at its most relevant: life—and your body—will never seem the same again.

There’s more to being human than you think. 

Have you ever wondered why so many people are overweight? Or why nearly half of youngsters have allergies? Has it ever seemed strange that depression is so common? Or that more and more children are being diagnosed with autism?

Using the latest scientific research, Alanna Collen reveals the link between ill health and the body’s community of microbes. Many of the modern illnesses we accept as part of life are instead newly emerging conditions brought on by our failure to cherish the extension of our human cells: our microbes. 

In 10% Human, Collen explains how messing with your microbes can affect your metabolism, your mind, and your immune system; why antibiotics, C-sections, and infant formula can cause collateral damage; and how diet can restore a beneficial community of microbes. 10% Human is an alarm call on behalf of our most faithful companions.


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