Edition :2
Year :2011
Description :
Although decades of laboratory and clinical research have led to incremental improvement in treatment outcome, lung cancer remains one of the most deadly diseases. In the second, completely updated edition of this comprehensive book, many of the world’s leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings. The first three sections cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for nonsmall cell and small cell lung cancer are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including IMRT, IMAT, cyber knife treatment, and tomotherapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer.
Table of contents : Front Matter....Pages i-xviii
Molecular Biology and Genetics of Lung Cancer....Pages 3-15
Angiogenesis and Lung Cancer....Pages 17-41
Interventional Pulmonology....Pages 45-52
Pathology of Lung Cancer....Pages 53-62
Radiologic Imaging of Lung Cancer....Pages 63-74
PET/CT for Staging and Diagnosis of Lung Cancer....Pages 75-88
Surgical Staging of Lung Cancer for Advances in Radiation Oncology of Lung Cancer....Pages 89-99
Lung Cancer Surgery....Pages 103-117
Radiation Response of the Normal Lung Tissue and Lung Tumors....Pages 119-128
Radiation Time, Dose, and Fractionation in the Treatment of Lung Cancer....Pages 129-141
3D Radiation Treatment Planning and Execution....Pages 143-156
Four-dimensional Radiation Therapy for Non-Small Cell Lung Cancer: A Clinical Perspective....Pages 157-172
PET and PET/CT in Treatment Planning....Pages 173-186
Target Volume Definition in Non-Small Cell Lung Cancer....Pages 187-200
The Radiation Target in Small-Cell Lung Cancer....Pages 201-212
Radiation Sensitizers....Pages 213-222
Radioprotectors and Chemoprotectors in the Management of Lung Cancer....Pages 223-245
Systemic Therapy for Lung Cancer for the Radiation Oncologist....Pages 247-266
Combined Radiotherapy and Chemotherapy: Theoretical Considerations and Biological Premises....Pages 267-273
Radiotherapy and Second Generation Drugs....Pages 275-290
Radiotherapy and Third Generation Concurrent Chemotherapy Agents....Pages 291-312
Conventional Radiation Therapy in Early Stage Non-small-cell Lung Cancer....Pages 315-341
Stereotactic Ablative Radiotherapy for Early Stage Lung Cancer....Pages 343-361
Postoperative Radiotherapy for Non-Small Cell Carcinoma....Pages 363-370
PDT-Lung....Pages 371-380
The Role of Radiofrequency Ablation in the Treatment of Stage 1 Non-Small Cell Lung Cancer....Pages 381-395
Lung Dose Escalation....Pages 399-408
Radiochemotherapy in Locally Advanced Nonsmall-Cell Lung Cancer....Pages 409-431
Tri-Modality Therapy in Locally Advanced Non-Small-Cell Lung Cancer....Pages 433-443
Prophylactic Cranial Irradiation....Pages 445-452
Palliative External Beam Thoracic Radiation Therapy of Non-Small Cell Lung Cancer....Pages 453-459
Intraoperative Radiotherapy in Lung Cancer: Methodology (Electrons or Brachytherapy), Clinical Experiences and Long-Term Institutional Results....Pages 461-476
Brachytherapy for Lung Cancer....Pages 477-488
Limited-Disease Small-Cell Lung Cancer....Pages 491-504
Radiation Therapy in Extensive Disease Small Cell Lung Cancer....Pages 505-511
Prophylactic Cranial Irradiation in Small-Cell Lung Cancer....Pages 513-520
Radiation Therapy for Lung Cancer in Elderly....Pages 523-542
Radiation Therapy for Recurrent Disease....Pages 543-559
Radiation Therapy for Metastatic Disease....Pages 561-573
Advances in Supportive and Palliative Care for Lung Cancer Patients....Pages 575-593
Hematological Toxicity in Lung Cancer....Pages 597-608
Radiation-Induced Lung and Heart Toxicity....Pages 609-625
Spinal Cord Toxicity....Pages 627-636
Radiation Therapy-Related Toxicity: Esophagus....Pages 637-645
Brain Toxicity....Pages 647-658
Quality of Life Outcomes in Radiotherapy of Lung Cancer....Pages 661-673
Prognostic Factors in Lung Cancer....Pages 675-688
Intensity-Modulated Radiation Therapy and Volumetric-Modulated Arc Therapy for Lung Cancer....Pages 691-713
Image-Guided Robotic Stereotactic Ablative Radiotherapy for Lung Tumors: The CyberKnife....Pages 715-724
Advances in Radiation Oncology of Lung Cancer....Pages 725-733
Image-Guided Radiotherapy in Lung Cancer....Pages 735-742
Proton Therapy for Lung Cancer: State of the Science....Pages 743-751
Carbon Ion Radiotherapy in Hypo-Fractionation Regimen and Single Dose for Stage I Non-small-Cell Lung Cancer....Pages 753-762
Novel Cytotoxic Agents in Combination with Radiation in the Management of Locally Advanced Non-Small Cell Lung Cancer: Focus on Pemetrexed and Nab-Paclitaxel [Abraxane]....Pages 765-771
Novel Targeted Agents and Radiopharmaceuticals in Lung Cancer....Pages 773-790
Translational Research in Lung Cancer....Pages 793-808
Clinical Research in Radiation Oncology of Lung Cancer: Why We Fail(ed)?....Pages 809-818
Pitfalls in the Design, Analysis, Presentation, and Interpretation of Randomized Clinical Trials....Pages 819-826
New Directions in the Evaluation and Presentation of Clinical Research in Lung Cancer....Pages 827-836
Back Matter....Pages 837-843
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