Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects

Authors : Ricardo Jorge Gelpi, Alberto Boveris, Juan José Poderoso  (eds.)
Edition :1
Year : 2016
Description :
The strongest point of this book titled “Biochemistry of Oxidative Stress: Physiopathology and Clinical Aspects”, is that the academic and scientific background of the authors/editors guarantee the authorship of a book comprising all aspects of oxidative stress, ranging from very molecular aspects, to clinical application, including the antioxidant therapy. Of particular importance is the fact that the aforementioned aspects are described in the book in a general section and in three different and important pathologies, such as cardiovascular diseases, neurodegenerative diseases, and cancer. The importance of these pathologies lays in the fact that, taken separately or together, they represent by far the leading cause of death in the world. Finally, all the chapters have been written by highly recognized authorities in the field of their investigations. At least to our knowledge, this is the first book with this characteristics in the field of oxidative stress.
Table of contents : Front Matter....Pages i-xi
Front Matter....Pages 1-1
The Concept of Oxidative Stress After 30 Years....Pages 3-11
The Evolution of the Earth and Its Atmosphere....Pages 13-22
Biochemistry and Physiology of Heart Mitochondrial Nitric Oxide Synthase....Pages 23-35
Biochemistry of Nitric Oxide and Peroxynitrite: Sources, Targets and Biological Implications....Pages 37-48
Nitro-arachidonic Acid: Downstream Signaling and Therapeutics....Pages 49-77
Mitochondrial Transfer by Intercellular Nanotubes....Pages 79-93
Human Adaptation to Life at High Altitude....Pages 95-108
Front Matter....Pages 109-126
Role of Oxidative Stress in Subcellular Defects in Ischemic Heart Disease....Pages 127-127
Reduced Oxidative Stress as a Mechanism for Increased Longevity, Exercise and Heart Failure Protection with Adenylyl Cyclase Type 5 Inhibition....Pages 129-146
Regulation of Protein Nitrosylation by Thioredoxin 1....Pages 147-161
Thioredoxin Attenuates Post-ischemic Damage in Ventricular and Mitochondrial Function....Pages 163-175
Antioxidant Supplementation in Cardiovascular Disease and Hypertension....Pages 177-191
Oxidative Stress Influence in the Development of Pulmonary Arterial Hypertension....Pages 193-212
Redox Regulation of Vascular Remodeling....Pages 213-226
Mitochondrial Complex I Inactivation After Ischemia-Reperfusion in the Stunned Heart....Pages 227-243
Reactive Oxygen Species Are Involved in Myocardial Remote Ischemic Preconditioning....Pages 245-257
Inhaled Particulate Matter Leads to Myocardial Dysfunction....Pages 259-274
Front Matter....Pages 275-285
Neurovascular Coupling Mediated by Neuronal Derived-Nitric Oxide: Mechanisms in Health and Dysfunction with Impact on Aging and Alzheimer’s Disease....Pages 287-287
Oxidative Stress and Neurodegeneration....Pages 289-308
Front Matter....Pages 309-325
Mitochondrial DNA Damage in Autism....Pages 287-287
Systemic Oxidative Stress in Patients with Neurodegenerative Diseases....Pages 327-343
Front Matter....Pages 345-358
Oxidative Stress, Metabolic Syndrome and Alzheimer’s Disease....Pages 359-359
Oxidative Stress and Antioxidants in Experimental Metabolic Syndrome....Pages 361-374
Mitochondrial Dynamics Regulates Oxidative Metabolism in Leydig Tumor Cells....Pages 375-390
Cancer and Mitochondria....Pages 391-408
Tumor Immunology and Immunotherapy in Cancer Patients....Pages 409-423
Back Matter....Pages 425-442
....Pages 443-454

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