HPV Infection in Head and Neck Cancer 2017

Authors :Wojciech Golusiński, C. René Leemans, Andreas Dietz (eds.)
Edition :1
Year :2017
Description :
This book is exceptional in presenting an interdisciplinary approach to the subject of human papillomavirus (HPV) infection in the context of head and neck cancer. Leading experts in the field discuss the epidemiology and molecular biology of HPV-positive head and neck squamous cell carcinoma, HPV testing, the nonsurgical and surgical treatment of HPV-positive tumors, predictive factors for outcome and quality of life, and ongoing trials on the effectiveness of vaccination in disease prevention. It also provides recommendations for testing, diagnosis treatment and vaccination. Otolaryngologists, head and neck surgeons, medical oncologists, radiation oncologists, molecular biologists and pathologists will find this book a valuable resource.

Table of contents : Front Matter....Pages i-vi
Front Matter....Pages 1-1
HPV in Head and Neck Cancer—30 Years of History....Pages 3-25
Epidemiology of HPV-Positive Tumors in Europe and in the World....Pages 27-35
Molecular Patterns and Biology of HPV-Associated HNSCC....Pages 37-56
HPV Integration in Head and Neck Squamous Cell Carcinomas: Cause and Consequence....Pages 57-72
Risk Factors for Oral Infection with Human Papillomavirus....Pages 73-85
Front Matter....Pages 87-87
HPV-Related Head and Neck Squamous Cell Carcinomas....Pages 89-100
HPV Testing of Head and Neck Cancer in Clinical Practice....Pages 101-111
Variation of HPV Subtypes with Focus on HPV-Infection and Cancer in the Head and Neck Region....Pages 113-122
Tumor Staging and HPV-Related Oropharyngeal Cancer....Pages 123-133
Front Matter....Pages 135-135
Human Papillomavirus (HPV): A Criterion for Therapeutic Decision in Squamous Cell Carcinoma of the Head and Neck?....Pages 137-147
Systemic Treatment in HPV-Induced Recurrent or Metastatic HNSCC....Pages 149-160
Optimizing Radiotherapy in HPV-Associated Oropharyngeal Cancer Patients....Pages 161-171
Should We De-escalate the Treatment for HPV-Positive Tumors?....Pages 173-181
Front Matter....Pages 183-183
The Role of Conventional Surgery in Oropharyngeal Cancer....Pages 185-195
The Role of Surgery in the Management of Recurrent Oropharyngeal Cancer....Pages 197-205
TORS in HPV-Positive Tumors—The New Standard?....Pages 207-218
Front Matter....Pages 219-219
Risk Groups for Survival in HPV-Positive and HPV-Negative OPSCC....Pages 221-231
Predictive Factors for Outcome and Quality of Life in HPV-Positive and HPV-Negative HNSCC....Pages 233-242
Cancer Immunology and HPV....Pages 243-248
Front Matter....Pages 249-249
Update on De-intensification and Intensification Studies in HPV....Pages 251-256
Front Matter....Pages 249-249
Vaccination Expectations in HNSCC....Pages 257-267


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