Innate Immunity and the Eye

Authors :

Manfred Zierhut, Friedrich Paulsen, Jerry Y. Niederkorn, Ulrich Schraermeyer

Edition :
Year : 2013
Description :
The role of the innate immune system has been underestimated over the years, but findings during the last decade have revealed how important it is in initiating and shaping the adaptive immune response.

The innate immune system comprises the cells and their mechanisms that defend the host from infection by antigens in a nonspecific manner. Therefore, this is a necessary supplement to the antigen specific or adaptive immune system. Both systems consist of humoral and cellular components, the innate system additionally also includes anatomical barriers.

This book will update our knowledge about the various cellular components (e.g. NK-cells, microglial cells, macrophages) and associated factors (e.g. antimicrobial peptides, mucins, toll-like receptors). Also, the cooperation of innate and adaptive immune system will be discussed. After presentation of the physiological role of the innate immune system, its role in autoimmune disorders, tumorigenesis and infection (e.g. TB) will be analyzed.
Key Features
The role of the innate immune system has been underestimated over the years, but findings during the last decade have revealed how important it is in initiating and shaping the adaptive immune response This book will update our knowledge about its role in infections, cancer and autoimmune disorders, and how it is involved in various ocular disorders, such as dry eye, viral keratitis, ocular transplantation, glaucoma, uveitis and age-related maculopathy.

Table of contents : 1 Role of the Innate Immune System - Friedrich Paulsen, Fabian Garreis, Lars Bräuer
2 Microglial Homeostasis: Lessons from the Mouse Retina - Marcus Karlstetter, Thomas Langmann
3 Keratinocyte-Derived Antimicrobial Peptides as Effectors in Innate Skin Defense - Jens-M Schröder
4 The Role of Mucins in the Innate Immune System - Anthony Corfield
5 Natural Killer Cells - Doris Urlaub, Sebastian Stark, Carsten Watzl
6 Role of T Cells and Dendritic Cells in Immune-Mediated Diseases - Christian Kurts
7 Toll-like Receptors: Structure and Ligand Specificities - Renato Ostuni, Ivan Zanoni, Francesca Granucci
8 Macrophages, Autoimmunity and Control of Tissue Damage - Andrew D. Dick
9 The Innate Immune Response to Cancer - Adelheid Cerwenka
10 Role of TNF in Host Resistance to Tuberculosis Infection: Membrane TNF is Sufficient to Control Infection - Muazzam Jacobs, Bernhard Ryffel
11 Innate Immunity of the External Eye - Lars Bräuer, Fabian Garreis, Martin Schicht, Friedrich Paulsen
12 Innate Immune System and its Impact on Immune Privilege in the Eye - Jerry Y. Niederkorn
13 Myeloid-Derived Cells in the Eye—Distribution, Turnover and Functional Correlates - P.G. McMenamin, J. Kezic, H.R. Chinnery
14 Linking the Innate and Adaptive Immune Response during the Immunopathogenesis of Dry Eye Disease - Michael E. Stern, Chris S. Schaumburg, Jerry Y. Niederkorn, Margarita Calonge, Stephen C. Pflugfelder
15 Innate Immune Control of Herpes Simplex Virus Replication in the Cornea - Gregory M. Frank, Kristine-Ann Buela, Robert L. Hendricks
17 The Innate Immune Response and Autoimmune Uveitis - Rachel R. Caspi
18 Innate Immunity of the Eye Glaucoma - Rudolf Fuchshofer
19 The Innate Immunity System and Age-Related Macular Degeneration - Ulrich Schraermeyer

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