Edition : 1
Year : 2015
Description :
This comprehensive volume presents data describing the role of oxidative stress in anterior eye disease. The content is divided into three logical parts: basic science of the cornea, basic science of the lens, and clinical practices. The first two parts include eighteen chapters that discuss topics ranging from oxidative stress and dry eye disease, endogenous protection of corneal cells against oxidative damage, the therapeutic potential of corneal stem cells, etiology of cataracts and preventive measures, corneal degeneration through oxidative stress and cataract formation, and function and dysregulation of ion channels and transporters in the ocular lens, among others. The concluding part is comprised of four chapters devoted to advancements in corneal surgery, cataract and diabetic retinopathy, the clinical treatment of cataracts including traumatic cataracts, and cataracts in the pediatric age group.
Studies on the Cornea and Lens is an essential addition to the library or department of physicians and researchers who treat or research these ocular conditions, particularly cataracts. It is also a key resource for cell biologists studying oxidative stress. This book is an authoritative contribution to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series.
Table of contents : Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Oxidative Stress in Cornea....Pages 3-22
Corneal Degenerations....Pages 23-38
Corneal Epithelial Nuclear Ferritin and Its Transporter Ferritoid Afford Unique Protection to DNA from UV Light and Reactive Oxygen Species....Pages 39-66
Excitatory Amino Acid Transporters, Xc − Antiporter, γ-Glutamyl Transpeptidase, Glutamine Synthetase, and Glutathione in Human Corneal Epithelial Cells....Pages 67-82
Transforming Growth Factor: β3 Regulates Cell Metabolism in Corneal Keratocytes and Fibroblasts....Pages 83-97
Corneal Stem Cells: A Source of Cell Renewal with Therapeutic Potential....Pages 99-113
New Agents for Treating Dry Eye Syndrome....Pages 115-129
Investigating Carcinine Transport and the Expression Profile of Transporter Genes in Human Corneal Epithelial Cells....Pages 131-144
Front Matter....Pages 145-145
Basic Review of the Oxidative Stress Role in Age-Related Cataractogenesis....Pages 147-154
The Human Lens: A Living Biometric Indicator of Health Status and Successful Aging....Pages 155-186
Oxidative Stress in Lens....Pages 187-207
Protein Serine/Threonine Phosphatases-1 and -2A in Lens Development and Pathogenesis....Pages 209-219
Proteases in Lens and Cataract....Pages 221-238
Photosensitized Oxidation of Lens Proteins Exposed to UVA-Visible Light at Low Oxygen Concentration: Its Effect on the Proteasome System....Pages 239-274
p53 Regulates Developmental Apoptosis and Gene Expression to Modulate Lens Differentiation....Pages 275-285
Etiology and Prevention of Cataract....Pages 287-315
The Effects of Lutein in Preventing Cataract Progression....Pages 317-326
Antioxidant Defense Network in the Lens and Benefits of Glutathione Prodrugs in Cataracts....Pages 327-359
Front Matter....Pages 361-361
Updates and Advances in Corneal Surgery....Pages 363-369
Cataract and Diabetic Retinopathy....Pages 371-383
Front Matter....Pages 361-361
Traumatic Cataract: A Review....Pages 385-413
Cataract in Pediatric Age Group: A Review....Pages 415-444
Back Matter....Pages 445-447
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