Drug transporters , 2 volume set

Authors : Glynis Nicholls, Glynis Nicholls, Kuresh Youdim, David Thurston, David Fox, Bruno Stieger

Edition :

Year : 2016

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field.

The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. 

As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential areas for future advances within the drug transporter field.

The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further. 

As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

Table of contents : Content: Cover
Contents
Preface
Acknowledgements
Abbreviations
Chapter 1 Emerging Transporter Science and Challenges for the Future
1.1 Introduction
1.2 Membrane Transporters of Emerging Importance
1.3 Membrane Transporters in Less-studied Organs and Tissues
1.3.1 Placenta
1.3.2 Retina
1.3.3 Heart
1.3.4 Skin
1.4 Organotypic In vitro Technologies
1.4.1 Microfluidics
1.4.2 3D Microplatforms
1.4.3 3D Bioprinting
1.5 Summary
References
Chapter 2 Enabling Dynamic Response to Chemical Challenge: Nuclear Receptor-mediated Control of Transporter Expression
2.1 General Introduction 2.2 Nuclear Receptor Overview2.2.1 General Introduction
2.2.2 Structure of Nuclear Receptors
2.3 Localisation and Function of Nuclear Receptors
2.3.1 Trans-activation
2.3.2 Trans-repression
2.4 Nuclear Receptors as Chemical Sensors
2.5 Nuclear Receptors and Drug Transporters
2.6 The ABC Superfamily
2.6.1 ABCA Subfamily
2.6.2 ABCB Subfamily
2.6.3 ABCC Subfamily
2.6.4 ABCD Subfamily
2.6.5 ABCE and ABCF Subfamilies
2.6.6 ABCG Subfamily
2.7 SLC Superfamily
2.7.1 Oligopeptide Transporters (SLC15A)
2.7.2 Folate Transporters (SLC19A) 2.7.3 Concentrative Nucleoside Transporters (SLC28A)2.7.4 Equilibrative Nucleoside Transporters (SLC29A)
2.7.5 Organic Anion Transporters (SLCO/SLC21)
2.7.6 Organic Cation Transporters (SLC22)
2.7.7 Multidrug and Toxin Extrusion Proteins (SLC47)
2.8 Conclusion
References
Chapter 3 Targeted Proteomics to Support Transporter IVIVE and PBPK
3.1 Introduction
3.1.1 In vitro to In vivo Extrapolation (IVIVE) of Transporter Activity
3.2 Methods for Quantitative Proteomics
3.2.1 Mass Spectrometry-based Proteomics 3.3 Utility of Transporter Proteomic Data in the Translation of Transporter Activity in Human Tissues3.3.1 IVIVE of Actively Transported Substrate Drugs
3.3.2 IVIVE and PBPK of Hepatobiliary Transport
3.3.3 IVIVE and PBPK of Intestinal Transport
3.3.4 IVIVE and PBPK of Transport Through the Blood-Brain Barrier
3.3.5 IVIVE and PBPK of Renal Transport
3.4 Current Status and Future Challenges
References
Chapter 4 Interplay Between Enzymes and Transporters: Impact on the Prediction of Pharmacokinetics and Drug-Drug Interactions
4.1 Introduction 4.2 Evidence of the Clinical Impact of the Interplay Between Enzymes and Transporters4.2.1 Impact of the Interplay Between Enzymes and Transporters on Absorption
4.2.2 Impact of the Interplay Between Enzymes and Transporters on Distribution
4.2.3 Impact of the Interplay Between Enzymes and Transporters on Elimination
4.2.4 Interplay Due to Regulation of Enzymes and Transporters
4.3 Prediction of the Impact of the Interplay Between Enzymes and Transporters on Pharmacokinetics
4.3.1 Preclinical Investigation of the Enzyme-Transporter Interplay

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-Volume 1 : http:dowg242F0

-Volume 2 : http:dowh8B589