Nanotherapeutics : from laboratory to clinic

Authors : Chowdhury, Ezharul Hoque
Edition : 1
Year : 2016
Description :

Features

• Bridges the gap for the first time between the preclinical development in the laboratory and the clinical evaluation and regulatory approval of nanotherapeutics
• Integrates all interdisciplinary components of nanotherapeutics from design/fabrication to final development
• Discusses strategic contributions of nanocarriers to improving the local delivery, sustained release, and pharmacokinetics of small drugs and macromolecular drugs depending on the routes of delivery
• Presents emerging approaches of nanomedicine in relation to their preclinical evaluations in animal models of diverse human diseases
• Provides an extensive database on the potential nanomedicine products under clinical trials and the approved ones in relation to their architectures, sponsors, and disease targets
• Depicts the critical and important issues with 71 completely new, vivid, and beautiful images

Summary

The emergence of nanotherapeutics is attributable to the integration of nanotechnology, recombinant DNA technology, and synthetic organic chemistry with medicine for treating critical human diseases in a more efficient and specific molecular approach than therapy with conventionally-designed and formulated drugs. Nanotherapeutics: From Laboratory to Clinic comprehensively discusses the current shortcomings for delivery of classical (small) drugs, macromolecular therapeutics, and recombinant vaccine via the common intravascular and extravascular routes.

The book describes the synthetic/chemical engineering methods as well as recombinant, hybridoma, and phage display technologies to fabricate different types of nanoparticulate carriers and drugs. It also reveals the diversified approaches undertaken by harnessing nanotechnology to overcome the multistep extracellular and intracellular barriers and to facilitate the development of novel strategies for therapeutic delivery and imaging. The author elaborates on the preclinical and clinical trials of potential nanoparticle-based products in animal models and patients and the approval/commercialization of nanotherapeutics, addressing all relevant human diseases.

A focus on the above issues in a concise but illustrative manner fills the gap between the laboratory findings originating from the research on identification of cellular and systemic barriers of classical and macromolecular drugs along with development of strategies for fabrication and testing of nanotherapeutics, and the clinical outcomes emanating from the testing of the selected potential nanotherapeutics on patients of particular diseases. The book also fills a gap in the existing literature between the design and development of diversified nanotherapeutics for various purposes and the investigation and evaluation of potential barriers and resultant therapeutic efficacy of those nano-medicine formulations.

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