A Short Guide for the Management of Transfusion Dependent Thalassaemia (TDT)

Authors :Farmakis, D. , Angastiniotis, M. , Eleftheriou, A.
Edition : 3
Year : 2014
Description :

The Latin characters I, II, III indicate the Class of Recommendation of the reviewed literature.
I: There is evidence and/or general agreement that a given treatment or procedure is beneficial, useful, effective.
II: There is conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of the given treatment or procedure.

• II a: the weight of evidence is in favour of the usefulness/ efficacy of the treatment or procedure and should therefore be considered.
• IIb: the usefulness/efficacy of the treatment or procedure is less well established by evidence/opinion and therefore may be considered.

III: There is evidence or general agreement that the given treatment or procedure is not useful/effective, and in some cases may be harmful.

The letters A, B, C indicate the level of evidence available in the reviewed literature, i.e., the strength of the results described in the guideline.

• A: Data  is  derived  from  multiple  well-designed randomized controlled trials or meta-analysis with a number of participants of sufficient statistical power.
• B: Data is derived from at least one large well-designed clinical trial with or without randomization, from cohort or case-control analytic studies, or well-designed meta-analysis.

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